New flu treatment calms immune response
Promising results in mice Canada Goose Jackets could lead to human trials.
The therapy dampens the body’s response to infection. It might also Canada Goose Online work for other diseases in which our defences overreact, such as asthma or multiple sclerosis, says one of its developers, Tracy Hussell of Imperial College, London. “There are canada goose uk shop many situations https://www.salecanadagooseoutlets.com/ where the immune system goes mad,” she canada goose clearance sale says.
Unlike vaccines canada goose coats on sale or antivirals, the new drug attacks cheap canada goose uk the symptoms of flu rather canada goose store than the canada goose clearance virus itself. So it should be unaffected by strains that mutate to dodge more direct attacks.
“It clearly has potential,” canada goose black friday sale says immunologist David Gray of the University of Edinburgh. Similar anti inflammatory drugs are already used to treat rheumatoid arthritis, he says, but other options would be uk canada goose outlet welcome: “One could have a whole range of buy canada goose jacket cheap these drugs to pick off the shelf for a particular disease.”
The cheap Canada Goose researchers studied mice infected with influenza A. This strain caused the Spanish flu pandemic of 1918 19, which killed more than 20 million people worldwide.
There canada goose factory sale is no guarantee that the drug Canada Goose UK Black Friday will work Canada Goose Parka in humans. “Flu isn’t a natural infection of mice,” warns influenza expert Alan Hay Canada Goose Outlet of the National Institute for Medical Research in London. “But it’s certainly something worth following up,” he says.
Enemy within A canada goose coats body with flu can be its own worst enemy. Immune sentries called T cells rush canada goose to the lungs, releasing chemicals that cause inflammation. This can be life threatening: it blocks blood vessels cutting off the body’s oxygen supply.
It Canada Goose online is not clear buy canada goose jacket why we mount such a counterproductive defence. It may be that the deep recesses of canadian goose jacket our lungs are unaccustomed to foreign canada goose uk black friday bodies, and so respond with unusual vigour.
Hussell’s team stops these overzealous T cells loitering in the lungs. Their treatment blocks a molecule on the cells’ surface called OX40. Normally, OX40 is switched on about two days after a T cell meets the flu virus, prolonging the cell’s life. The protein that blocks OX40 Canada Goose Coats On Sale was originally developed to treat inflammatory bowel disease. T cells stream into the lungs, but not in numbers that cause severe inflammation. The cells are efficient virus killers in the two days before they switch on OX40, and those that have not encountered flu carry on as normal.
Infected mice normally lose a quarter of their body weight, Canada Goose sale and become feverish. A drug dose three days after exposure kept them healthy1. “They didn’t look infected at all,” says Hussell.
Wrong diagnosis should not be uk canada goose a problem, Hussell adds. Common cold viruses produce the same immune response, and the treatment should canada goose uk outlet work just as well.
The researchers are seeking funding for a clinical trial in healthy humans and, if that goes well, in asthmatics. Barring any setback, a drug is five to ten years away.